PRMT8

Across TCGA cell cohorts, PRMT8 RNA expression is significantly associated with the go_rna of many other GO terms, with 746 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible PRMT8-associated GO terms across cancer lineages are Positive regulation of respiratory gaseous exchange, Monosaccharide transmembrane transport, and Negative regulation of bone mineralization involved in bone maturation. Each is linked with PRMT8 in more than 3 cancer types. Because this analysis shows association rather than direction, both PRMT8-to-partner and partner-to-PRMT8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of respiratory gaseous exchange grouped by PRMT8-low versus PRMT8-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PRMT8→partner) and Y-score (partner→PRMT8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of respiratory gaseous exchange →	+1.058	+0.502	.001	.002	3	4
BONE	Monosaccharide transmembrane transport →	-0.113	-0.669	<.001	.002	3	3
BONE	Negative regulation of bone mineralization involved in bone maturation →	-1.178	-0.459	.002	.007	3	3
BONE	Regulation of systemic arterial blood pressure by circulatory renin-angiotensin →	-0.181	-0.536	.001	<.001	3	3
BONE	Regulation of osteoblast proliferation →	-0.196	-0.514	<.001	.004	3	3
BONE	Negative regulation of transmission of nerve impulse →	+1.503	+0.491	.002	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 746 associations by consensus.

Positive regulation of respiratory gaseous exchange by PRMT8 expression — BONE

Explore this box plot interactively →