PRMT8

Across TCGA cell cohorts, PRMT8 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible PRMT8-associated genes across cancer lineages are MAGEB4, LUZP4, and NEUROD4. Each is linked with PRMT8 in more than 1 cancer types. Because this analysis shows association rather than direction, both PRMT8-to-partner and partner-to-PRMT8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAGEB4 grouped by PRMT8-low versus PRMT8-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRMT8→partner) and Y-score (partner→PRMT8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MAGEB4 →	+0.012	+5.415	.009	.004	3	1
BLOOD_Lymphoma	LUZP4 →	+0.066	+4.350	<.001	.005	3	1
BLOOD_Lymphoma	NEUROD4 →	+0.151	+4.714	<.001	.002	3	1
BLOOD_Lymphoma	ESX1 →	+0.019	+4.643	<.001	.005	3	1
BLOOD_Lymphoma	ABCG8 →	+0.017	+4.191	.001	.007	3	1
BLOOD_Lymphoma	DPPA2 →	+0.345	+4.523	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

MAGEB4 by PRMT8 expression — LARGE_INTESTINE

Explore this box plot interactively →