protein arginine methyltransferase 5 pseudogene 1Genealiases: []
Q-omics provides the consensus-scored PRMT5P1 profile across patient tissues and cancer cell-line models. PRMT5P1 expression is associated with patient survival in 13 of 34 cancer types, with the highest sampling consensus in KIRP. Among the 18 cancer types available for tumor–normal comparison, PRMT5P1 is differentially expressed in 2, with the highest sampling consensus in COAD. Additionally, PRMT5P1 RNA expression shows 7,904 significant protein co-abundance associations, with the highest sampling consensus in BRCA. Together, these results highlight KIRP, COAD, and BRCA as cancer lineages where PRMT5P1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for PRMT5P1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes PRMT5P1 survival associations across molecular data types. PRMT5P1 RNA expression shows survival associations in the most cancer types (13). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible PRMT5P1 RNA expression–survival associations across cancer types. High PRMT5P1 expression shows unfavorable associations in KIRP, MESO, UCEC and KICH, but favorable associations in UCS and READ. The KIRP Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRP as the clearest survival context for PRMT5P1 RNA expression.
This table summarizes PRMT5P1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 2. The strongest signals are observed in COAD for RNA.
This table ranks reproducible tumor–normal expression differences for PRMT5P1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. PRMT5P1 shows higher tumor expression in COAD and KICH. The COAD box plot shows higher PRMT5P1 RNA expression in tumor versus normal tissue (log2 FC = +0.098, t-test p = .003).
This table shows molecular features associated with PRMT5P1 in patient tissues and cancer cell lines. In patient samples, PRMT5P1 shows the broadest associations at the RNA and protein expression levels, with BRCA recurring as the lineage with the largest associated feature set.
