PRMT5

Across TCGA patient cohorts, PRMT5 mutation is significantly associated with the RNA expression of many other genes, with 1,156 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRMT5-associated genes across cancer lineages are MTATP6P21, RN7SL248P, and RNA5SP285. Each is linked with PRMT5 in more than 2 cancer types. Because this analysis shows association rather than direction, both PRMT5-to-partner and partner-to-PRMT5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTATP6P21 grouped by PRMT5-low versus PRMT5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRMT5→partner) and Y-score (partner→PRMT5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MTATP6P21 →	+0.248	+1.867	<.001	.007	3	3
UCEC	RN7SL248P →	+0.056	+3.059	<.001	.005	3	3
LGG	RNA5SP285 →	+0.315	+6.032	<.001	.002	3	2
UCEC	CRYBB2P1 →	+0.431	+2.815	.004	.001	3	2
UCEC	TLE6 →	+0.693	+1.786	.002	.008	3	2
UCEC	SETDB2 →	+0.412	+2.947	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,156 associations by consensus.

MTATP6P21 by PRMT5 expression — UCEC

Explore this box plot interactively →