PRLHR

Across TCGA patient cohorts, PRLHR mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRLHR-associated genes across cancer lineages are VEGFR2, c-Myc, and Src_pY416. Each is linked with PRLHR in more than 1 cancer types. Because this analysis shows association rather than direction, both PRLHR-to-partner and partner-to-PRLHR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VEGFR2 grouped by PRLHR-low versus PRLHR-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRLHR→partner) and Y-score (partner→PRLHR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	VEGFR2 →	+0.272	+3.459	.036	.005	3	2
UCEC	c-Myc →	-0.289	-3.321	.007	.010	3	2
COAD	Src_pY416 →	+0.315	+2.815	.037	.036	3	1
UCEC	14-3-3_beta →	-0.112	-3.143	.010	.018	3	1
UCEC	JNK2 →	+0.245	+2.834	.004	.034	3	1
UCEC	Ku80 →	+0.270	+3.331	.009	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

VEGFR2 by PRLHR expression — UCEC

Explore this box plot interactively →