PRL

Across TCGA patient cohorts, PRL mutation is significantly associated with the RNA expression of many other genes, with 2,305 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRL-associated genes across cancer lineages are MIR4774, OR4D6, and OR8D1. Each is linked with PRL in more than 2 cancer types. Because this analysis shows association rather than direction, both PRL-to-partner and partner-to-PRL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4774 grouped by PRL-low versus PRL-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRL→partner) and Y-score (partner→PRL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	MIR4774 →	+0.627	+5.257	<.001	.002	3	3
CESC	OR4D6 →	+0.052	+5.554	<.001	<.001	3	2
CESC	OR8D1 →	+0.032	+4.757	<.001	.004	3	2
CESC	RNU6-1085P →	+0.378	+3.705	<.001	.008	3	2
UCEC	C17orf98 →	+0.368	+2.600	<.001	<.001	3	2
UCEC	GTSE1-DT →	+0.417	+2.850	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,305 associations by consensus.

MIR4774 by PRL expression — READ

Explore this box plot interactively →