PRKY

Across TCGA patient cohorts, PRKY mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible PRKY-associated genes across cancer lineages are OR2BH1P, TIMM9P1, and PSMB7P1. Each is linked with PRKY in more than 1 cancer types. Because this analysis shows association rather than direction, both PRKY-to-partner and partner-to-PRKY results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2BH1P grouped by PRKY-low versus PRKY-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRKY→partner) and Y-score (partner→PRKY) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	OR2BH1P →	+0.059	+7.810	<.001	<.001	3	1
SKCM	TIMM9P1 →	+0.322	+4.979	<.001	.009	3	1
SKCM	PSMB7P1 →	+0.093	+6.469	<.001	.001	3	1
SKCM	SRIP2 →	+0.254	+5.680	<.001	.003	3	1
SKCM	ZBTB45P2 →	+0.030	+5.292	.002	.006	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

OR2BH1P by PRKY expression — SKCM

Explore this box plot interactively →