PRKY

Across TCGA pan-cancer cohorts, PRKY RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of PRKY’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where PRKY RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PRKY is over-expressed in tumor, although a few such as THCA and PRAD show the opposite, repressed pattern.

KIRC, CHOL, and THCA are the cancer types where PRKY tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PRKY RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	IV	+0.556	<.001	5	view →
CHOL	Male	All	+2.043	<.001	4	view →
THCA	Female	All	−0.044	.004	3	view →
PRAD	All	All	−0.543	<.001	2	view →
KICH	Male	III,IV	−0.852	.011	1	view →
KIRP	Male	II,III,IV	−0.483	.038	1	view →
LIHC	Male	III,IV	+0.260	.045	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

PRKY–KIRC

Open the KIRC breakdown →