PRKX-AS1

Across TCGA pan-cancer cohorts, PRKX-AS1 RNA is linked to patient survival in 15 of 34 cancer types, making it the most broadly survival-associated PRKX-AS1 data layer.

The strongest signal is observed in ovarian serous cystadenocarcinoma (OV), where higher PRKX-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PRKX-AS1 expression acts as an unfavorable survival marker, although some lineages such as LUSC and LAML show a favorable association.

OV, READ, and LUSC are the cancer types where PRKX-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
OV	DFS	Tertile	IV	0.305	0.542	.013	24	view →
READ	DFS	Tertile	IV	0.402	0.658	.013	24	view →
LUSC	DFS	Quartile	All	0.740	0.593	.013	18	view →
LAML	DFS	Quartile	All	0.680	0.246	.012	16	view →
PAAD	DFS	Tertile	III,IV	0.275	0.794	.008	15	view →
COAD	OS	Tertile	IV	0.163	0.571	.014	9	view →
LIHC	DFS	Tertile	III,IV	0.571	0.145	.045	9	view →
LGG	DFS	Quartile	All	0.234	0.453	.008	9	view →
THYM	DFS	Median	All	0.625	0.883	.006	8	view →
KIRC	DFS	Quartile	IV	0.319	0.529	.009	6	view →
KIRP	OS	Tertile	II,III,IV	0.962	0.791	.033	6	view →
UCS	OS	Tertile	All	0.823	0.624	.029	4	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 15 lineages.

PRKX-AS1–OV (DFS)

Open the OV breakdown →