PRKX-AS1

Across TCGA pan-cancer cohorts, PRKX-AS1 RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of PRKX-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where PRKX-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types PRKX-AS1 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, KICH, and COAD are the cancer types where PRKX-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PRKX-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Female	All	−0.198	<.001	5	view →
KICH	All	All	−0.103	.009	4	view →
COAD	Male	II,III,IV	+0.108	.029	2	view →
LUAD	All	III,IV	−0.121	.012	1	view →
HNSC	Male	III,IV	+0.102	.028	1	view →
LUSC	All	All	+0.077	.036	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

PRKX-AS1–THCA

Open the THCA breakdown →