Across TCGA patient cohorts, PRKN RNA expression is significantly associated with the protein abundance of many other proteins, with 16,853 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PRKN-associated proteins across cancer lineages are BBS2, BBS7, and ADD3. Each is linked with PRKN in more than 6 cancer types. Because this analysis shows association rather than direction, both PRKN-to-partner and partner-to-PRKN results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PRKN→partner) and Y-score (partner→PRKN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	BBS2 →	+0.599	+0.499	<.001	<.001	3	7
PDAC	BBS7 →	+0.329	+0.407	<.001	<.001	3	6
BRCA	ADD3 →	+0.342	+0.248	.004	.008	3	6
LSCC	CRMP1 →	+0.845	+0.501	<.001	<.001	3	6
HNSC	EIF3M →	-0.165	-0.478	<.001	<.001	3	6
LSCC	ERO1A →	-0.465	-0.388	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,853 associations by consensus.

Exploration

PRKN survival (RNA) · tumor vs normal (RNA) · all PRKN data types