Across TCGA pan-cancer cohorts, PRKN RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated PRKN data layer compared with 11 for mutation status and 3 for mass-spec protein.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher PRKN RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated PRKN expression acts as an unfavorable survival marker, although some lineages such as KIRC and ACC show a favorable association.
KIRC, LUAD, and ACC are the cancer types where PRKN RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.