Across TCGA patient cohorts, PRKN protein abundance is significantly associated with the RNA expression of many other genes, with 12,758 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PRKN-associated genes across cancer lineages are CAVIN2, CDKN3, and HELLS. Each is linked with PRKN in more than 5 cancer types. Because this analysis shows association rather than direction, both PRKN-to-partner and partner-to-PRKN results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRKN→partner) and Y-score (partner→PRKN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	CAVIN2 →	+1.572	+0.445	<.001	<.001	3	6
LSCC	CDKN3 →	-1.032	-0.459	<.001	<.001	3	5
LSCC	HELLS →	-0.926	-0.415	<.001	<.001	3	5
BRCA	NCAPH →	-0.985	-0.804	.002	<.001	3	5
LSCC	KNTC1 →	-0.690	-0.393	<.001	<.001	3	5
LSCC	ERCC6L →	-0.880	-0.426	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,758 associations by consensus.

Exploration

PRKN survival (RNA) · tumor vs normal (RNA) · all PRKN data types