Across TCGA patient cohorts, PRKN mutation is significantly associated with the RNA expression of many other genes, with 2,582 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRKN-associated genes across cancer lineages are CHEK1, KIFC1, and NCAPH. Each is linked with PRKN in more than 3 cancer types. Because this analysis shows association rather than direction, both PRKN-to-partner and partner-to-PRKN results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRKN→partner) and Y-score (partner→PRKN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CHEK1 →	+0.658	+3.831	<.001	<.001	3	4
SKCM	KIFC1 →	+0.563	+2.935	.003	<.001	3	4
SKCM	NCAPH →	+0.644	+3.719	.001	<.001	3	4
UCEC	CHAF1A →	+0.669	+2.850	<.001	.001	3	3
UCEC	FEN1 →	+0.648	+3.711	.001	<.001	3	3
UCEC	LMNB2 →	+0.739	+4.008	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,582 associations by consensus.

Exploration

PRKN survival (RNA) · tumor vs normal (RNA) · all PRKN data types