Across TCGA patient cohorts, PRKN mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRKN-associated genes across cancer lineages are Notch1, STAT3_pY705, and ATM. Each is linked with PRKN in more than 2 cancer types. Because this analysis shows association rather than direction, both PRKN-to-partner and partner-to-PRKN results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRKN→partner) and Y-score (partner→PRKN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.160	+1.765	.002	.014	3	2
UCEC	STAT3_pY705 →	-0.269	-2.459	.006	.018	3	2
UCEC	ATM →	-0.411	-2.169	.015	.003	2	3
LUSC	S6_pS240_S244 →	+0.512	+2.825	.023	.033	3	1
SKCM	GSK3-a-b →	-0.199	-2.000	.004	.031	3	1
SKCM	Caveolin-1 →	-0.753	-3.169	.006	.017	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

Exploration

PRKN survival (RNA) · tumor vs normal (RNA) · all PRKN data types