Across TCGA cell cohorts, PRKN RNA expression is significantly associated with the go_rna of many other GO terms, with 2,739 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PRKN-associated GO terms across cancer lineages are Negative regulation of glucokinase activity, Mitochondrion to lysosome vesicle-mediated transport, and Mitochondrion-derived vesicle mediated transport. Each is linked with PRKN in more than 13 cancer types. Because this analysis shows association rather than direction, both PRKN-to-partner and partner-to-PRKN results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PRKN→partner) and Y-score (partner→PRKN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Negative regulation of glucokinase activity →	-0.328	-0.979	<.001	<.001	2	14
SOFT_TISSUE	Mitochondrion to lysosome vesicle-mediated transport →	-0.202	-0.597	<.001	.003	3	12
SOFT_TISSUE	Mitochondrion-derived vesicle mediated transport →	-0.202	-0.597	<.001	.003	3	12
KIDNEY	Negative regulation of excitatory postsynaptic potential →	-0.222	-0.894	<.001	<.001	3	11
BONE	Regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway →	-0.164	-0.523	.004	.008	3	10
SOFT_TISSUE	Response to curcumin →	+0.396	+1.103	.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,739 associations by consensus.

Exploration

PRKN survival (RNA) · tumor vs normal (RNA) · all PRKN data types