Across TCGA cell cohorts, PRKN mutation is significantly associated with the drug of many other genes, with 39 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PRKN-associated genes across cancer lineages are EPZ5676, AZD8055, and Rapamycin. Each is linked with PRKN in more than 1 cancer types. Because this analysis shows association rather than direction, both PRKN-to-partner and partner-to-PRKN results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRKN→partner) and Y-score (partner→PRKN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	EPZ5676 →	+0.429	+2.822	.023	.041	3	1
LARGE_INTESTINE	AZD8055 →	+0.604	+2.765	.011	.032	3	1
LARGE_INTESTINE	Rapamycin →	+0.684	+2.807	.002	.045	3	1
LARGE_INTESTINE	Oxaliplatin →	+0.579	+2.900	.019	.015	2	2
LARGE_INTESTINE	WZ4003 →	+0.523	+2.991	.006	.018	3	1
LARGE_INTESTINE	IRAK4_4710 →	+0.442	+2.649	.014	.046	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

Exploration

PRKN survival (RNA) · tumor vs normal (RNA) · all PRKN data types