Across TCGA pan-cancer cohorts, PRKG1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated PRKG1 data layer compared with 25 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher PRKG1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated PRKG1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LUAD show a favorable association.

CCRCC, LUAD, and LSCC are the cancer types where PRKG1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	III,IV	0.728	0.442	.019	7	view →
LUAD	DFS	Median	All	0.955	0.656	.010	6	view →
LSCC	OS	Quartile	II,III,IV	0.712	0.944	.040	4	view →
HNSC	DFS	Median	III,IV	0.875	0.732	.045	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: PRKG1 tumor-vs-normal RNA expression · all PRKG1 data types