Across TCGA patient cohorts, PRKG1 protein abundance is significantly associated with the RNA expression of many other genes, with 18,568 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PRKG1-associated genes across cancer lineages are MYL9, ACTA2, and FHL5. Each is linked with PRKG1 in more than 9 cancer types. Because this analysis shows association rather than direction, both PRKG1-to-partner and partner-to-PRKG1 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRKG1→partner) and Y-score (partner→PRKG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MYL9 →	+1.448	+0.763	<.001	<.001	3	10
OV	ACTA2 →	+2.222	+0.860	<.001	<.001	3	10
CCRCC	FHL5 →	+1.345	+0.654	<.001	<.001	3	10
CCRCC	TEK →	+1.173	+0.558	<.001	<.001	3	10
OV	PDE1B →	+0.843	+0.676	<.001	<.001	3	10
CCRCC	ISLR →	+1.835	+0.674	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,568 associations by consensus.

Exploration

PRKG1 survival (RNA) · tumor vs normal (RNA) · all PRKG1 data types