Across TCGA patient cohorts, PRKG1 mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRKG1-associated genes across cancer lineages are Notch1, PDCD4, and Caspase-7-cleavedD198. Each is linked with PRKG1 in more than 3 cancer types. Because this analysis shows association rather than direction, both PRKG1-to-partner and partner-to-PRKG1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRKG1→partner) and Y-score (partner→PRKG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.105	+1.691	.010	.011	3	4
SKCM	PDCD4 →	-0.418	-2.415	.009	.003	3	4
UCEC	Caspase-7-cleavedD198 →	+0.456	+1.604	.008	.005	3	3
LUSC	p62 Lck ligand →	+0.612	+2.179	.025	.035	3	2
STAD	p38-MAPK_pT180_Y182 →	-0.406	-3.000	.033	.036	3	2
UCEC	EGFR_pY1068 →	-0.191	-1.925	.009	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

Exploration

PRKG1 survival (RNA) · tumor vs normal (RNA) · all PRKG1 data types