Across TCGA cell cohorts, PRKG1 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,986 significant associations in total. BONE shows the largest number of these associations.

The most reproducible PRKG1-associated GO terms across cancer lineages are Collateral sprouting, Relaxation of smooth muscle, and Relaxation of vascular associated smooth muscle. Each is linked with PRKG1 in more than 10 cancer types. Because this analysis shows association rather than direction, both PRKG1-to-partner and partner-to-PRKG1 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PRKG1→partner) and Y-score (partner→PRKG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Collateral sprouting →	-0.202	-0.648	.004	<.001	3	11
SOFT_TISSUE	Relaxation of smooth muscle →	-0.247	-1.587	<.001	<.001	3	10
BONE	Relaxation of vascular associated smooth muscle →	-0.224	-2.012	<.001	<.001	3	9
LUNG_SCLC	Negative regulation of vascular associated smooth muscle cell migration →	-0.246	-0.796	<.001	.001	3	8
SKIN	Gamma-aminobutyric acid signaling pathway →	-0.141	-0.611	<.001	.003	3	8
LIVER	Actin filament fragmentation →	+0.120	+0.773	.005	.006	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,986 associations by consensus.

Exploration

PRKG1 survival (RNA) · tumor vs normal (RNA) · all PRKG1 data types