PRKG1-AS1

Across TCGA pan-cancer cohorts, PRKG1-AS1 RNA is linked to patient survival in 16 of 34 cancer types, making it the most broadly survival-associated PRKG1-AS1 data layer.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher PRKG1-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PRKG1-AS1 expression acts as an unfavorable survival marker, although some lineages such as UCS and LGG show a favorable association.

LUAD, HNSC, and COAD are the cancer types where PRKG1-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	All	0.255	0.447	<.001	155	view →
HNSC	OS	Median	All	0.267	0.446	<.001	124	view →
COAD	OS	Median	All	0.717	0.874	.001	55	view →
BLCA	DFS	Median	III,IV	0.366	0.499	.001	48	view →
PAAD	DFS	Tertile	All	0.142	0.418	<.001	46	view →
OV	DFS	Tertile	All	0.489	0.610	.002	34	view →
UCS	DFS	Quartile	II,III,IV	0.609	0.233	.018	18	view →
GBM	OS	Quartile	All	0.209	0.459	.011	16	view →
STAD	DFS	Median	IV	0.337	0.458	.015	15	view →
MESO	OS	Tertile	All	0.242	0.475	.015	14	view →
DLBC	OS	Tertile	II,III,IV	0.586	0.949	.014	11	view →
LGG	OS	Tertile	All	0.953	0.824	.001	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 16 lineages.

PRKG1-AS1–LUAD (DFS)

Open the LUAD breakdown →