PRKG1-AS1

Across TCGA pan-cancer cohorts, PRKG1-AS1 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of PRKG1-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where PRKG1-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PRKG1-AS1 is over-expressed in tumor, although a few such as BLCA and UCEC show the opposite, repressed pattern.

HNSC, LUAD, and LIHC are the cancer types where PRKG1-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PRKG1-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+0.191	<.001	11	view →
LUAD	All	All	+0.156	.019	4	view →
LIHC	All	All	+0.054	.013	3	view →
BLCA	Male	All	−0.214	.025	2	view →
UCEC	All	IV	−0.065	.005	2	view →
PRAD	All	All	−0.052	.037	2	view →
ESCA	Female	All	−0.173	.008	1	view →
THCA	All	All	−0.030	.015	1	view →
KIRC	Male	IV	−0.027	.039	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

PRKG1-AS1–HNSC

Open the HNSC breakdown →