Across TCGA patient cohorts, PRKD1 mutation is significantly associated with the total protein of many other genes, with 67 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRKD1-associated genes across cancer lineages are PKC-a_pS657, S6_pS240_S244, and BRCA2. Each is linked with PRKD1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PRKD1-to-partner and partner-to-PRKD1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRKD1→partner) and Y-score (partner→PRKD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PKC-a_pS657 →	-0.306	-2.982	.007	.034	3	3
UCEC	S6_pS240_S244 →	+0.460	+2.263	<.001	<.001	3	3
UCEC	BRCA2 →	-0.123	-3.278	.004	.009	3	3
UCEC	Caspase-7-cleavedD198 →	+0.721	+2.522	<.001	<.001	3	3
STAD	eEF2 →	+0.499	+3.000	.001	.036	3	2
STAD	beta-Catenin →	+0.887	+3.000	.018	.036	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 67 associations by consensus.

Exploration

PRKD1 survival (RNA) · tumor vs normal (RNA) · all PRKD1 data types