PRKCQ

Across TCGA patient cohorts, PRKCQ mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRKCQ-associated genes across cancer lineages are Annexin-1, MYH11, and p53. Each is linked with PRKCQ in more than 2 cancer types. Because this analysis shows association rather than direction, both PRKCQ-to-partner and partner-to-PRKCQ results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Annexin-1 grouped by PRKCQ-low versus PRKCQ-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRKCQ→partner) and Y-score (partner→PRKCQ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Annexin-1 →	+0.409	+2.700	.006	.005	3	3
SKCM	MYH11 →	-0.747	-1.938	.008	.001	3	2
SKCM	p53 →	+0.150	+1.169	.015	.033	3	2
UCEC	Caspase-8 →	-0.254	-4.221	.002	<.001	3	2
UCEC	PDCD4 →	-0.422	-1.700	.006	.040	3	2
SKCM	HER3 →	+0.304	+2.115	.025	.015	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

Annexin-1 by PRKCQ expression — SKCM

Explore this box plot interactively →