PRKCQ

Across TCGA pan-cancer cohorts, PRKCQ RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of PRKCQ’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where PRKCQ RNA is repressed in tumor relative to normal tissue. In most cancer types PRKCQ is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

KIRC, KICH, and THCA are the cancer types where PRKCQ tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PRKCQ RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	II,III,IV	−1.836	<.001	12	view →
KICH	Male	All	−3.818	<.001	11	view →
THCA	Male	III,IV	−2.152	<.001	11	view →
LUAD	Female	III,IV	−2.104	<.001	9	view →
LUSC	Male	III,IV	−2.375	<.001	8	view →
BRCA	All	III,IV	−0.755	.005	6	view →
COAD	All	All	+0.446	.002	5	view →
CHOL	Female	All	+2.196	<.001	3	view →
BLCA	Male	III,IV	+1.520	.027	2	view →
KIRP	All	All	−0.874	.005	2	view →
PRAD	All	All	−0.410	.002	2	view →
STAD	Female	III,IV	+1.114	.012	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

PRKCQ–KIRC

Open the KIRC breakdown →