PRKCQ

Across TCGA cell cohorts, PRKCQ RNA expression is significantly associated with the go_rna of many other GO terms, with 3,603 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PRKCQ-associated GO terms across cancer lineages are Ventricular cardiac muscle cell action potential, Heterochromatin formation, and Negative regulation of mRNA catabolic process. Each is linked with PRKCQ in more than 8 cancer types. Because this analysis shows association rather than direction, both PRKCQ-to-partner and partner-to-PRKCQ results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ventricular cardiac muscle cell action potential grouped by PRKCQ-low versus PRKCQ-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PRKCQ→partner) and Y-score (partner→PRKCQ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Ventricular cardiac muscle cell action potential →	-0.125	-0.665	.002	.002	3	9
BREAST	Heterochromatin formation →	+0.038	+0.646	.003	.004	3	8
BREAST	Negative regulation of mRNA catabolic process →	+0.050	+0.922	.009	.009	3	7
OVARY	Cytoplasmic translation →	+0.075	+1.019	<.001	.002	3	7
LARGE_INTESTINE	Positive regulation of interleukin-4 production →	-0.098	-0.584	<.001	.002	3	7
BLOOD_Leukemia	Regulation of hematopoietic stem cell proliferation →	+0.096	+1.232	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,603 associations by consensus.

Ventricular cardiac muscle cell action potential by PRKCQ expression — LARGE_INTESTINE

Explore this box plot interactively →