PRKCQ

Across TCGA cell cohorts, PRKCQ mutation is significantly associated with the RNA expression of many other genes, with 37 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PRKCQ-associated genes across cancer lineages are GPR119, MRGPRE, and OTUD6A. Each is linked with PRKCQ in more than 1 cancer types. Because this analysis shows association rather than direction, both PRKCQ-to-partner and partner-to-PRKCQ results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GPR119 grouped by PRKCQ-low versus PRKCQ-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRKCQ→partner) and Y-score (partner→PRKCQ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	GPR119 →	+0.025	+4.867	<.001	.009	3	2
BLOOD_Lymphoma	MRGPRE →	+0.019	+5.209	<.001	.005	3	2
BLOOD_Lymphoma	OTUD6A →	+0.113	+5.209	<.001	.005	3	2
BLOOD_Lymphoma	TEX13A →	+0.036	+5.643	<.001	.002	3	2
SOFT_TISSUE	CLPS →	+0.092	+4.392	<.001	.004	3	1
BREAST	CFC1B →	+0.005	+4.781	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

GPR119 by PRKCQ expression — BLOOD_Lymphoma

Explore this box plot interactively →