PRKCG

Across TCGA pan-cancer cohorts, PRKCG Mutation is linked to patient survival in 9 of 34 cancer types, making it a survival-associated PRKCG data layer compared with 26 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher PRKCG Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated PRKCG expression acts as an unfavorable survival marker, although some lineages such as UCEC and LUSC show a favorable association.

KIRP, LGG, and OV are the cancer types where PRKCG Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	II,III,IV	0.132	0.772	<.001	26	view →
LGG	OS	Median	All	0.163	0.896	<.001	12	view →
OV	OS	Median	IV	0.022	0.760	<.001	12	view →
LIHC	DFS	Median	All	0.099	0.546	<.001	12	view →
UCEC	DFS	Median	All	0.918	0.618	.014	8	view →
CESC	OS	Median	All	0.144	0.589	.027	4	view →
LUAD	DFS	Median	IV	0.671	0.893	.019	4	view →
SKCM	DFS	Median	IV	0.040	0.432	.038	3	view →
LUSC	OS	Median	All	0.959	0.767	.020	1	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

PRKCG–KIRP (OS)

Open the KIRP breakdown →