PRKCE

Across TCGA patient cohorts, PRKCE mutation is significantly associated with the RNA expression of many other genes, with 3,764 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRKCE-associated genes across cancer lineages are HDAC9-AS1, ZSCAN22, and LIG1. Each is linked with PRKCE in more than 2 cancer types. Because this analysis shows association rather than direction, both PRKCE-to-partner and partner-to-PRKCE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HDAC9-AS1 grouped by PRKCE-low versus PRKCE-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRKCE→partner) and Y-score (partner→PRKCE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	HDAC9-AS1 →	+0.174	+5.303	<.001	.006	3	3
UCEC	ZSCAN22 →	+0.257	+2.078	.003	<.001	3	3
UCEC	LIG1 →	+0.447	+1.986	<.001	<.001	3	3
CESC	RN7SL658P →	+0.086	+4.144	<.001	.009	3	2
LUSC	RNA5SP462 →	+0.550	+2.976	.002	.006	3	2
CESC	OR5M1 →	+0.027	+4.569	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,764 associations by consensus.

HDAC9-AS1 by PRKCE expression — HNSC

Explore this box plot interactively →