PRKCE

Across TCGA pan-cancer cohorts, PRKCE RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of PRKCE’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where PRKCE RNA is repressed in tumor relative to normal tissue. In most cancer types PRKCE is over-expressed in tumor, although a few such as THCA and LUAD show the opposite, repressed pattern.

THCA, LUAD, and KIRP are the cancer types where PRKCE tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PRKCE RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−1.254	<.001	11	view →
LUAD	Female	III,IV	−1.950	<.001	9	view →
KIRP	Male	II,III,IV	−1.372	<.001	9	view →
LUSC	Female	II,III,IV	−2.642	<.001	8	view →
KIRC	All	IV	−0.650	<.001	8	view →
COAD	Male	All	−0.524	<.001	8	view →
READ	All	III,IV	−0.954	.007	6	view →
BRCA	Female	All	−0.309	<.001	6	view →
BLCA	Male	All	−0.537	.016	3	view →
UCEC	All	All	−0.796	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

PRKCE–THCA

Open the THCA breakdown →