PRKCE

Across TCGA patient cohorts, PRKCE mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRKCE-associated genes across cancer lineages are ACC_pS79, JNK_pT183_Y185, and Cyclin-B1. Each is linked with PRKCE in more than 2 cancer types. Because this analysis shows association rather than direction, both PRKCE-to-partner and partner-to-PRKCE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACC_pS79 grouped by PRKCE-low versus PRKCE-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRKCE→partner) and Y-score (partner→PRKCE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ACC_pS79 →	+0.228	+1.874	.032	.049	3	3
UCEC	JNK_pT183_Y185 →	-0.145	-1.502	.004	.027	3	3
UCEC	Cyclin-B1 →	+0.617	+2.415	<.001	.002	3	3
UCEC	EGFR →	-0.167	-1.678	<.001	.021	3	2
UCEC	Ku80 →	+0.183	+1.487	.011	.004	3	2
UCEC	Rab25 →	-0.250	-3.807	.013	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

ACC_pS79 by PRKCE expression — UCEC

Explore this box plot interactively →