PRKCE

Across TCGA cell cohorts, PRKCE mutation is significantly associated with the RNA expression of many other genes, with 267 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PRKCE-associated genes across cancer lineages are SH3GL2, USP14, and EFCC1. Each is linked with PRKCE in more than 1 cancer types. Because this analysis shows association rather than direction, both PRKCE-to-partner and partner-to-PRKCE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SH3GL2 grouped by PRKCE-low versus PRKCE-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRKCE→partner) and Y-score (partner→PRKCE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SH3GL2 →	+0.397	+3.215	.002	.005	3	2
LARGE_INTESTINE	USP14 →	+0.663	+3.299	.005	.004	3	1
LARGE_INTESTINE	EFCC1 →	+0.583	+3.299	.001	.004	3	1
LARGE_INTESTINE	METTL8 →	+0.927	+3.212	<.001	.006	3	1
LARGE_INTESTINE	ATG4C →	+0.590	+3.212	.001	.006	3	1
LARGE_INTESTINE	YARS1 →	+0.714	+3.212	.006	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 267 associations by consensus.

SH3GL2 by PRKCE expression — BLOOD_Leukemia

Explore this box plot interactively →