Across TCGA pan-cancer cohorts, PRKCE-AS1 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated PRKCE-AS1 data layer.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher PRKCE-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated PRKCE-AS1 expression acts as an unfavorable survival marker, although some lineages such as LUSC and COAD show a favorable association.

KIRP, LUSC, and COAD are the cancer types where PRKCE-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Tertile	II,III,IV	0.407	0.776	.002	84	view →
LUSC	OS	Tertile	II,III,IV	0.760	0.552	<.001	65	view →
COAD	OS	Quartile	II,III,IV	0.881	0.562	.008	54	view →
MESO	OS	Tertile	III,IV	0.352	0.603	.027	45	view →
ACC	DFS	Tertile	III,IV	0.046	0.670	.001	45	view →
PAAD	OS	Median	All	0.561	0.305	.005	33	view →
CESC	OS	Median	II,III,IV	0.883	0.668	.003	20	view →
TGCT	DFS	Tertile	All	0.322	0.821	<.001	18	view →
LUAD	DFS	Tertile	All	0.568	0.252	<.001	17	view →
LIHC	DFS	Tertile	All	1.000	0.289	.018	15	view →
HNSC	DFS	Median	II,III,IV	0.762	0.571	.010	10	view →
UVM	DFS	Tertile	III,IV	0.107	0.677	.004	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

Exploration

Same gene, other analysis: PRKCE-AS1 tumor-vs-normal RNA expression · all PRKCE-AS1 data types