PRKCB

Across TCGA cell cohorts, PRKCB mutation is significantly associated with the RNA expression of many other genes, with 339 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PRKCB-associated genes across cancer lineages are SLC38A8, MBD3L4, and TRIM51. Each is linked with PRKCB in more than 1 cancer types. Because this analysis shows association rather than direction, both PRKCB-to-partner and partner-to-PRKCB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC38A8 grouped by PRKCB-low versus PRKCB-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRKCB→partner) and Y-score (partner→PRKCB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	SLC38A8 →	+0.050	+3.606	.003	.002	3	2
LUNG_NSCLC_LUAD	MBD3L4 →	+0.013	+4.681	<.001	.003	3	2
PANCREAS	TRIM51 →	+0.025	+4.614	<.001	.004	3	1
PANCREAS	UNCX →	+0.027	+4.614	<.001	.004	3	1
BLOOD_Myeloma	SERPINA7 →	+0.459	+4.807	<.001	.006	3	1
BLOOD_Myeloma	C1orf158 →	+0.053	+4.807	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 339 associations by consensus.

SLC38A8 by PRKCB expression — BLOOD_Lymphoma

Explore this box plot interactively →