PRKCA

Across TCGA patient cohorts, PRKCA RNA expression is significantly associated with the protein abundance of many other proteins, with 14,194 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible PRKCA-associated proteins across cancer lineages are PRKCA_S226, PRKCD, and GSN. Each is linked with PRKCA in more than 6 cancer types. Because this analysis shows association rather than direction, both PRKCA-to-partner and partner-to-PRKCA results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PRKCA versus PRKCA_S226 in BRCA, with a Pearson correlation of 0.60.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PRKCA→partner) and Y-score (partner→PRKCA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PRKCA_S226 →	+0.754	+0.857	<.001	<.001	3	7
GBM	PRKCD →	-0.346	-0.441	<.001	.003	3	5
BRCA	GSN →	+0.804	+0.787	<.001	<.001	3	5
UCEC	AIDA →	+0.349	+0.827	<.001	<.001	3	5
LSCC	MAP1B_S1965 →	+0.838	+0.462	<.001	<.001	3	5
BRCA	PDLIM4 →	+0.560	+0.676	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,194 associations by consensus.

PRKCA vs PRKCA_S226 — BRCA

Explore this scatter interactively →