PRKCA

Across TCGA pan-cancer cohorts, PRKCA RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated PRKCA data layer compared with 5 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher PRKCA RNA is associated with worse overall survival. In most high-consensus cancer types, elevated PRKCA expression acts as an unfavorable survival marker, although some lineages such as ACC and LGG show a favorable association.

UVM, CESC, and MESO are the cancer types where PRKCA RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.396	0.839	<.001	129	view →
CESC	DFS	Median	All	0.647	0.845	<.001	94	view →
MESO	OS	Quartile	All	0.337	0.684	.001	67	view →
ACC	DFS	Median	All	0.739	0.437	<.001	49	view →
LGG	DFS	Tertile	All	0.889	0.732	<.001	32	view →
LUSC	DFS	Tertile	III,IV	0.461	0.714	.014	28	view →
READ	OS	Tertile	III,IV	0.758	0.294	.008	27	view →
UCEC	DFS	Median	III,IV	0.671	0.471	.013	24	view →
LIHC	DFS	Median	All	0.469	0.617	<.001	22	view →
THCA	OS	Quartile	All	0.882	0.992	.010	20	view →
ESCA	DFS	Median	II,III,IV	0.339	0.895	.007	18	view →
HNSC	OS	Quartile	All	0.711	0.816	.009	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

PRKCA–UVM (OS)

Open the UVM breakdown →