PRKCA

Across TCGA patient cohorts, PRKCA mutation is significantly associated with the RNA expression of many other genes, with 3,095 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRKCA-associated genes across cancer lineages are VTRNA2-2P, RN7SL810P, and SGTA. Each is linked with PRKCA in more than 2 cancer types. Because this analysis shows association rather than direction, both PRKCA-to-partner and partner-to-PRKCA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VTRNA2-2P grouped by PRKCA-low versus PRKCA-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRKCA→partner) and Y-score (partner→PRKCA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	VTRNA2-2P →	+0.251	+3.431	.003	.003	3	3
READ	RN7SL810P →	+0.518	+6.257	<.001	.001	3	2
UCEC	SGTA →	+0.506	+2.436	<.001	<.001	3	2
SKCM	DMAC2 →	+0.373	+3.198	.004	.009	3	2
SKCM	ANAPC15 →	+0.525	+2.706	<.001	.003	3	2
SKCM	PPP1R7 →	+0.351	+3.360	.005	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,095 associations by consensus.

VTRNA2-2P by PRKCA expression — CESC

Explore this box plot interactively →