PRKCA

Across TCGA patient cohorts, PRKCA mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRKCA-associated genes across cancer lineages are Annexin-1, TFRC, and Ku80. Each is linked with PRKCA in more than 1 cancer types. Because this analysis shows association rather than direction, both PRKCA-to-partner and partner-to-PRKCA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Annexin-1 grouped by PRKCA-low versus PRKCA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRKCA→partner) and Y-score (partner→PRKCA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Annexin-1 →	+0.562	+2.169	<.001	.002	3	2
UCEC	TFRC →	+0.485	+2.700	.003	.005	3	2
SKCM	Ku80 →	+0.334	+3.000	.034	.036	2	2
UCEC	14-3-3_beta →	-0.074	-1.558	.018	.032	3	1
UCEC	eIF4E →	+0.197	+3.820	.002	<.001	3	1
UCEC	ERK2 →	+0.120	+1.415	.047	.043	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

Annexin-1 by PRKCA expression — UCEC

Explore this box plot interactively →