PRKCA

Across TCGA cell cohorts, PRKCA RNA expression is significantly associated with the RNA expression of many other genes, with 11,503 significant associations in total. CNS shows the largest number of these associations.

The most reproducible PRKCA-associated genes across cancer lineages are ZEB1, DPY19L1, and SH2B3. Each is linked with PRKCA in more than 10 cancer types. Because this analysis shows association rather than direction, both PRKCA-to-partner and partner-to-PRKCA results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PRKCA versus ZEB1 in URINARY_TRACT, with a Pearson correlation of 0.69.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRKCA→partner) and Y-score (partner→PRKCA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	ZEB1 →	+2.642	+1.821	<.001	<.001	3	11
BREAST	DPY19L1 →	+1.956	+2.496	<.001	<.001	3	10
CNS	SH2B3 →	+1.889	+1.552	<.001	.002	3	10
BONE	LOXL2 →	+4.118	+2.174	<.001	<.001	3	10
BONE	PIP4K2A →	+1.329	+2.512	<.001	<.001	3	10
LUNG_NSCLC_LUSC	TRIO →	+1.633	+2.343	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,503 associations by consensus.

PRKCA vs ZEB1 — URINARY_TRACT

Explore this scatter interactively →