PRKCA

Across TCGA cell cohorts, PRKCA RNA expression is significantly associated with the go_rna of many other GO terms, with 5,297 significant associations in total. BONE shows the largest number of these associations.

The most reproducible PRKCA-associated GO terms across cancer lineages are Regulation of angiotensin-activated signaling pathway, Regulation of dense core granule biogenesis, and Positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway. Each is linked with PRKCA in more than 17 cancer types. Because this analysis shows association rather than direction, both PRKCA-to-partner and partner-to-PRKCA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of angiotensin-activated signaling pathway grouped by PRKCA-low versus PRKCA-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PRKCA→partner) and Y-score (partner→PRKCA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation of angiotensin-activated signaling pathway →	+0.244	+2.328	<.001	<.001	3	18
STOMACH	Regulation of dense core granule biogenesis →	+1.067	+2.355	<.001	<.001	3	16
LUNG_NSCLC_LUSC	Positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway →	+0.370	+1.804	<.001	<.001	3	14
SOFT_TISSUE	Protein kinase C signaling →	+0.384	+2.025	.004	<.001	3	13
LIVER	Hepatocyte growth factor receptor signaling pathway →	+0.242	+1.854	.002	<.001	3	12
BONE	Negative regulation of glial cell apoptotic process →	+0.173	+2.351	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,297 associations by consensus.

Regulation of angiotensin-activated signaling pathway by PRKCA expression — BONE

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