PRKCA

Across TCGA cell cohorts, PRKCA mutation is significantly associated with the RNA expression of many other genes, with 330 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PRKCA-associated genes across cancer lineages are DEFA6, MC3R, and KRTAP4-4. Each is linked with PRKCA in more than 1 cancer types. Because this analysis shows association rather than direction, both PRKCA-to-partner and partner-to-PRKCA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DEFA6 grouped by PRKCA-low versus PRKCA-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRKCA→partner) and Y-score (partner→PRKCA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	DEFA6 →	+0.174	+4.562	<.001	<.001	3	2
BLOOD_Leukemia	MC3R →	+0.014	+4.984	<.001	.002	3	2
LUNG_SCLC	KRTAP4-4 →	+0.156	+5.169	<.001	<.001	3	2
BLOOD_Lymphoma	OR11H1 →	+0.027	+4.058	<.001	.009	3	2
BLOOD_Myeloma	PNLIP →	+0.046	+4.807	<.001	.006	3	1
BLOOD_Myeloma	TPRX1 →	+0.006	+4.807	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 330 associations by consensus.

DEFA6 by PRKCA expression — SKIN

Explore this box plot interactively →