PRKCA-AS1

Across TCGA pan-cancer cohorts, PRKCA-AS1 RNA is linked to patient survival in 13 of 34 cancer types, making it the most broadly survival-associated PRKCA-AS1 data layer.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher PRKCA-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated PRKCA-AS1 expression acts as an unfavorable survival marker, although some lineages such as LGG and PAAD show a favorable association.

COAD, ESCA, and THCA are the cancer types where PRKCA-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Quartile	IV	0.363	0.735	<.001	43	view →
ESCA	DFS	Quartile	All	0.217	0.877	.002	25	view →
THCA	DFS	Tertile	III,IV	0.183	0.667	.022	24	view →
BLCA	OS	Quartile	All	0.151	0.410	.010	10	view →
DLBC	DFS	Tertile	II,III,IV	0.373	0.836	.027	9	view →
READ	DFS	Tertile	IV	0.369	0.700	.034	7	view →
LGG	OS	Tertile	All	0.691	0.442	.009	7	view →
PAAD	OS	Median	II,III,IV	0.712	0.525	.035	5	view →
KIRC	OS	Quartile	All	0.493	0.679	.014	5	view →
KIRP	DFS	Tertile	All	0.342	0.767	.016	5	view →
SARC	OS	Median	All	0.794	0.885	.028	4	view →
UCEC	DFS	Tertile	IV	0.872	0.520	.034	4	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 13 lineages.

PRKCA-AS1–COAD (OS)

Open the COAD breakdown →