PRKCA-AS1

Across TCGA pan-cancer cohorts, PRKCA-AS1 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of PRKCA-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in stomach adenocarcinoma (STAD), where PRKCA-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PRKCA-AS1 is over-expressed in tumor, although a few such as BRCA and THCA show the opposite, repressed pattern.

STAD, LIHC, and UCEC are the cancer types where PRKCA-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PRKCA-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
STAD	All	All	+0.176	.004	4	view →
LIHC	Male	All	+0.023	<.001	4	view →
UCEC	All	IV	+0.320	.033	2	view →
BRCA	All	III,IV	−0.020	.012	2	view →
THCA	All	All	−0.007	.016	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

PRKCA-AS1–STAD

Open the STAD breakdown →