PRKAR2B-AS1

Across TCGA pan-cancer cohorts, PRKAR2B-AS1 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated PRKAR2B-AS1 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher PRKAR2B-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated PRKAR2B-AS1 expression acts as an unfavorable survival marker, although some lineages such as LUSC and LIHC show a favorable association.

KIRC, ACC, and HNSC are the cancer types where PRKAR2B-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.553	0.688	<.001	139	view →
ACC	OS	Median	All	0.442	0.843	<.001	101	view →
HNSC	DFS	Median	III,IV	0.130	0.366	.002	44	view →
LUSC	DFS	Quartile	III,IV	0.701	0.253	.006	32	view →
LAML	DFS	Quartile	All	0.470	0.739	.006	24	view →
LGG	OS	Quartile	All	0.638	0.841	<.001	24	view →
KICH	DFS	Median	III,IV	0.285	0.900	.005	16	view →
LIHC	DFS	Quartile	II,III,IV	0.597	0.368	.006	15	view →
CESC	OS	Quartile	IV	0.235	0.659	.003	12	view →
BRCA	OS	Quartile	III,IV	0.961	0.869	.022	12	view →
DLBC	DFS	Tertile	All	0.938	0.445	.014	12	view →
READ	OS	Tertile	II,III,IV	1.000	0.505	.031	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

PRKAR2B-AS1–KIRC (OS)

Open the KIRC breakdown →