PRKAR2B-AS1

Across TCGA pan-cancer cohorts, PRKAR2B-AS1 RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of PRKAR2B-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where PRKAR2B-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types PRKAR2B-AS1 is over-expressed in tumor, although a few such as THCA and KIRC show the opposite, repressed pattern.

THCA, KIRC, and KICH are the cancer types where PRKAR2B-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PRKAR2B-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Female	III,IV	−0.072	<.001	6	view →
KIRC	All	All	−0.024	.003	5	view →
KICH	All	All	−0.046	.007	4	view →
UCEC	All	IV	+0.070	.019	2	view →
HNSC	Male	II,III,IV	+0.020	.021	2	view →
KIRP	All	All	−0.024	.027	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

PRKAR2B-AS1–THCA

Open the THCA breakdown →