PRKAR2A

Across TCGA pan-cancer cohorts, PRKAR2A mass-spec protein is linked to patient survival in 1 of 34 cancer types, making it a survival-associated PRKAR2A data layer compared with 27 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher PRKAR2A mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated PRKAR2A expression acts as an unfavorable survival marker, although some lineages such as LUAD show a favorable association.

LUAD are the cancer types where PRKAR2A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	All	0.997	0.924	.014	10	view →

Pink = unfavorable, green = favorable. Showing the 1 strongest of 1 lineages.

PRKAR2A–LUAD (OS)

Open the LUAD breakdown →