PRKAR2A

Across TCGA patient cohorts, PRKAR2A protein abundance is significantly associated with the RNA expression of many other genes, with 16,183 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible PRKAR2A-associated genes across cancer lineages are MTFR2, NEIL3, and NCAPG. Each is linked with PRKAR2A in more than 7 cancer types. Because this analysis shows association rather than direction, both PRKAR2A-to-partner and partner-to-PRKAR2A results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PRKAR2A versus MTFR2 in BRCA, with a Pearson correlation of -0.59.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRKAR2A→partner) and Y-score (partner→PRKAR2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MTFR2 →	-0.900	-0.263	<.001	<.001	3	8
LSCC	NEIL3 →	-0.783	-0.204	<.001	<.001	3	8
BRCA	NCAPG →	-1.054	-0.258	<.001	<.001	3	8
LSCC	RAD51AP1 →	-1.051	-0.233	<.001	<.001	3	8
LUAD	NEK2 →	-1.162	-0.219	<.001	<.001	3	8
UCEC	CENPF →	-1.505	-0.220	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,183 associations by consensus.

PRKAR2A vs MTFR2 — BRCA

Explore this scatter interactively →