PRKAR2A

Across TCGA patient cohorts, PRKAR2A mutation is significantly associated with the immune_cell of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PRKAR2A-associated genes across cancer lineages are Preadipocytes, aDC, and Macrophages M2. Each is linked with PRKAR2A in more than 1 cancer types. Because this analysis shows association rather than direction, both PRKAR2A-to-partner and partner-to-PRKAR2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Preadipocytes grouped by PRKAR2A-low versus PRKAR2A-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PRKAR2A→partner) and Y-score (partner→PRKAR2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Preadipocytes →	+0.073	+4.169	<.001	.027	3	1
UCEC	aDC →	+0.080	+2.180	.038	.036	3	1
UCEC	Macrophages M2 →	+0.011	+2.287	.042	.030	3	1
UCEC	pDC →	+0.058	+2.180	.023	.036	2	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

Preadipocytes by PRKAR2A expression — COAD

Explore this box plot interactively →