PRKAR2A

Across TCGA cell cohorts, PRKAR2A RNA expression is significantly associated with the go_rna of many other GO terms, with 3,897 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PRKAR2A-associated GO terms across cancer lineages are DNA-templated transcription elongation, Chemokine (C-C motif) ligand 21 signaling pathway, and Transcription initiation at RNA polymerase I promoter. Each is linked with PRKAR2A in more than 14 cancer types. Because this analysis shows association rather than direction, both PRKAR2A-to-partner and partner-to-PRKAR2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA-templated transcription elongation grouped by PRKAR2A-low versus PRKAR2A-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PRKAR2A→partner) and Y-score (partner→PRKAR2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	DNA-templated transcription elongation →	+0.079	+0.981	.004	.006	2	15
URINARY_TRACT	Chemokine (C-C motif) ligand 21 signaling pathway →	+0.186	+0.911	<.001	<.001	3	13
OESOPHAGUS	Transcription initiation at RNA polymerase I promoter →	+0.114	+0.804	.002	.001	2	14
OVARY	Regulation of chromosome condensation →	+0.129	+0.695	<.001	.004	3	12
UPPER_AERODIGESTIVE_TRACT	Transcription by RNA polymerase I →	+0.103	+0.931	.001	.001	3	12
PANCREAS	Phosphatidylinositol metabolic process →	+0.051	+0.709	<.001	.006	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,897 associations by consensus.

DNA-templated transcription elongation by PRKAR2A expression — OESOPHAGUS

Explore this box plot interactively →